Allelic and nonallelic homology of a supergene family.
نویسندگان
چکیده
منابع مشابه
Allelic and nonallelic homology of a supergene family.
A model to explain the high degree of polymorphism at the major histocompatibility complex (MHC) is described. The model incorporates domain transfer between the different loci in a supergene family by either gene conversion or double unequal crossing-over. Population genetics theory is used to formulate changes in the probabilities of allelic and nonallelic gene identities and equilibrium valu...
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The vertebrate immune response employs two categories of cells that react specifically with antigens: B lymphocytes react with soluble antigens and T lymphocytes react with antigens that are present on cell surfaces. The receptor molecules that mediate these specific immune responses have similar heterodimeric structures: light (L) and heavy(H) polypeptides for immunoglobulins serve as the anti...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1982
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.79.10.3251